The president at the novel's center possesses a personality whose high-speed alternations between charm and petulance, resoluteness and self-pity, continually energize and mystify the panoply of characters around him. They include his acerbic, crafty mother, former First Lady Barbara Bush; his desperately correct and eager-to-please secretary of state, Condoleezza Rice; the gnomic and manipulative Donald Rumsfeld; foreign leaders from Tony Blair to Vladimir Putin; and the caustic one-woman chorus of Ann Richards, Bush's predecessor as governor of Texas. A gallery of political and media figures, from the widowed Nancy Reagan to the philandering John Edwards to the brilliantly contrarian Christopher Hitchens, bring the novel and the era to life.

The story is deepened and driven by a love affair between two West Texans, Ross Weatherall and Allison O'Connor, whose destinies have been affixed to Bush's since they were teenagers in the 1970s. The true believer and the skeptic who end up exchanging ideological places in a romantic and political drama that unfolds in locations from New Orleans to Baghdad and during the parties, press conferences, and state funerals of Washington, D.C.