The East End of London has been devastated by the Blitz and the people are struggling to come to terms with their ravaged city. Rationing bites ever deeper and and everything that makes life better is in short supply. For the district nurses, the challenges are tougher than ever.

Gladys loves her work in the Civil Nursing Reserve, but just when she needs to rely on her sister at home to help out with the chores, she turns into a handful of trouble. Edith is learning to cope with her boyfriend's injuries after Dunkirk but will she have to choose between her love for him and her career?

With no end in sight, the war reaches its darkest moment ... Can the nurses - and the families and patients that rely on them - find the strength to carry on?