Sherlock Holmes' adventures continue in thirteen surprising cases.

In Part One, Holmes and Watson investigate an alleged haunting at the Diogenes Club, vandalism at a prominent art gallery, the case of a frightened amnesiac, the takeover of 221B by vicious criminals, the sequel to "The Engineer's Thumb," the defiling of Holmes' Stradivarius violin, and a Christmas story featuring a graveyard with angry insults carved into the headstones.

In Part Two, Holmes solves cases in alternate universes and alongside famous historical and fictional figures. In the title story, Watson is slandered by mysterious forces who spread the rumor that the good doctor pushed Holmes off of Reichenbach Falls. In other cases, Holmes solves a real-life murder aboard a train; partners with G.K. Chesterton's Father Brown in a murder case; helps the crusading lawyer Grace Quackenbos Humiston (affectionately nicknamed "Mrs. Sherlock Holmes"); seeks out someone capable of filling his brother Mycroft's shoes; and investigates a plagiarism lawsuit involving H.G. Wells. The game is afoot!