Freddy Trujillo is on the worst vacation of his life. After a rejected proposal, Freddy cheats on his boyfriend and must salvage the rest of the trip with his sister and her boyfriend.

Meanwhile, something has killed all Jim Walker's chickens. Once the sun sets, he and his son, Clive, hunt for the creature that drained the fowl. Clive is attacked by wild pigs. A needle-fanged, hairless monster comes to Clive's rescue and he names her Cooter, keeping her a secret, not knowing she's a chupacabra.

Jim takes Clive on a snake hunt to recoup the cost of the lost chickens but the two are attacked by Curious Ol' Bob, a bisexual skunk ape, and they barely make it out alive.

Freddy and his family are camping in the same everglades and it's up to Clive and Cooter to save them from Curious Ol' Bob.