A Tale of Two Cities is set in London and Paris before and during the French Revolution. The novel depicts the plight of the French peasantry demoralized by the French aristocracy in the years leading up to the revolution, the corresponding brutality demonstrated by the revolutionaries toward the former aristocrats in the early years of the revolution, and many unflattering social parallels with life in London during the same period. It follows the lives of several characters through these events.

A Tale of Two Cities was published in weekly installments from April 1859 to November 1859 in Dickens's new literary periodical titled All the Year Round. All but three of Dickens's previous novels had appeared only as monthly installments. With sales of about 200 million copies, A Tale of Two Cities is the biggest selling novel in history.