Winona Cole, an orphaned child of the Lakota Indians, finds herself growing up in an unconventional household on a farm in west Tennessee. Raised by her adoptive parents John Cole and Thomas McNulty, whose story Barry told in his acclaimed previous novel Days Without End, she forges a life for herself beyond the violence and dispossession of her past.

Tennessee is a state still riven by the bitter legacy of the Civil War, and the fragile harmony of her family is soon threatened by a further traumatic event, one which Winona struggles to confront, let alone understand. Exquisitely written, A Thousand Moons is a stirring, poignant story of love and redemption, of one woman's journey and her determination to write her own future.