AI for Defense and Intelligence is a timely and compelling read for graduate students interested in this rapidly-growing field, mid-career professionals looking to rebrand, and senior leaders in federal agencies who want to get smart on the latest tech. This approachable and focused book provides an overview of AI basics, a review of powerful machine learning models, and a discussion of applications across natural language processing (NLP), computer vision (CV), optimization, agent-based modeling and more. Readers will learn about contemporary defense and intelligence programs leveraging AI for mission advantage. The book also details challenges and solutions for scaling AI in the cloud, training models at scale, customizing AI for unique mission applications, and addressing hard problems endemic to defense and intelligence missions. The book quotes extensively from current research and government documents, providing the student with a strong basis for a career applying AI in support of national security.