Scotland, the 11th Century. Born in a noble household and granddaughter of a forgotten Scottish king, a young girl carries the guilt of her mother's death and the weight of an unknowable prophecy. When she is married, at fifteen, to the Mormaer of Moray, she experiences firsthand the violence of a sadistic husband and a kingdom constantly at war. To survive with her young son in a superstitious realm, she must rely on her own cunning and wit, especially when her husband's downfall inadvertently sets them free.

Suspicious of the dark devices that may have led to his father's death, her son watches as his mother falls in love with the enigmatic thane Macbeth. Now a woman of stature, Lady Macbeth confronts a world of masculine power and secures the protection of her family. But the coronation of King Duncan and the political maneuvering of her cousin Macduff set her on a tragic course, one where her own success might mean embracing the very curse that haunts her and risking the child she loves.