Ten years ago, Las Vegas was terrorized by a vicious and bloodthirsty serial killer responsible for nearly half a dozen brutal murders. But after two years of keeping the city in a panic, the killer mysteriously vanished and has not been heard from...until now.

Gil Grissom and his CSI team are called in to investigate a homicide that perfectly fits the notorious criminal's modus operandi. But all hell breaks loose when a reporter made famous by the original cases receives a letter from someone claiming to be the very same killer--but he insists that he had nothing to do with the latest slaying.

Now the CSI team must stop someone who may be a copycat killer from striking again, even as a murderer from the past continues to evade capture, and isn't taking too kindly to rivals.