Breakthrough chronicles Karikó's relentless pursuit of knowledge and dedication to helping people, depicting her as an inspirational figure for readers interested in science. The book contextualizes Karikó's work within her upbringing in a small village in rural Hungary, the discrimination she faced as an immigrant and woman scientist, and the COVID-19 pandemic. Accessible descriptions of the science behind mRNA support the main narrative, and profiles of other significant figures in the development of the mRNA vaccine illustrate how scientific achievement is never earned alone.