In the autumn of 1928, herbalist and healer Callie Beecham owns a shop in tiny Pickens, South Carolina. She makes her living treating patients with plant-based medicines and therapies. When a young man urgently knocks on her door one morning, Callie finds her world turned upside down. He begs Callie to come to the freed-slave settlement of Liberia, at the foot of the Blue Ridge Mountains, to save his wife, struggling in childbirth. On the back of a mule, Callie follows the man to Liberia and discovers a world previously unknown to her. Callie's decision to help the residents of Liberia quickly angers the wrong people in town-important people who know a secret about her, These people threaten Callie's livelihood, her relationships and even her life. Their goal? To remove Callie Beecham and her kind once and for all.