My name is Lisa di Antonio Gherardini Giocondo, though to acquaintances, I am known simply as Madonna Lisa. My story begins not with my birth but a murder, committed the year before I was born...

Florence, April 1478: The handsome Giuliano de' Medici is brutally assassinated in Florence's magnificent Duomo. The shock of the murder ripples throughout the great city, from the most renowned artists like Leonardo da Vinci and Michelangelo, to a wealthy wool merchant and his extraordinarily beautiful daughter, Madonna Lisa.

More than a decade later, Florence falls under the dark spell of the preacher Savonarola, a fanatic who burns paintings and books as easily as he sends men to their deaths. Lisa, now grown into an alluring woman, captures the heart of Giuliano's nephew and namesake. But when Guiliano, her love, meets a tragic end, Lisa must gather all her courage and cunning to untangle a sinister web of illicit love, treachery, and dangerous secrets that threatens her life.

Set against the drama of 15th Century Florence, I, Mona Lisa is painted in many layers of fact and fiction, with each intricately drawn twist told through the captivating voice of Mona Lisa herself.