Treating patients more humanely starts with promoting cultural competence and cultural humility. These concepts are critical to enhancing the medical experience for underserved communities and rebuilding their trust (confianza) in clinicians and the healthcare system. Given vast health-related disparities and their increase due to the COVID-19 pandemic, the need for innovative approaches to medical humanities is urgent. This collection brings together essays from both scholars and health practitioners that adopt either a cultural humility approach or a focus on social justice to shed new light on inequities. As the chapters in this volume illustrate, the medical humanities have a role in bringing down the barriers that prevent marginalized groups from having equitable access to health care. The essays address topics ranging from autism and aphasia to endometriosis, COVID-19, and Ebola with regions spanning the U.S., Latin America, and Africa.