Philadelphia, 1875: It is the start of term at Woman's Medical College of Pennsylvania. Dr. Lydia Weston, professor and anatomist, is immersed in teaching her students in the lecture hall and hospital. When the body of a patient, Anna Ward, is dredged out of the Schuylkill River, the young chambermaid's death is deemed a suicide. But Lydia is suspicious and she is soon brought into the police investigation.

Aided by a diary filled with cryptic passages of poetry, Lydia discovers more about the young woman she thought she knew. Through her skill at the autopsy table and her clinical acumen, Lydia draws nearer the truth. Soon a terrible secret, long hidden, will be revealed. But Lydia must act quickly, before she becomes the next target of those who wished to silence Anna.