Returning home to a post-apocalyptic Colorado after years spent hunting down the people responsible for his father's death, Jack Brooks finds his sister in the last stages of a horrible plague. Shortly before her death, she reveals that she had a premonition that Jack's destiny lies far to the north, where he will find something of great value that he must protect with his life. While not fully convinced of her psychic gift, Jack feels lost after her death, so he leaves home and heads north to Canada. There he meets Annie, a mysterious young woman accompanied by a massive timber wolf. Annie is on the run and seeks Jack's help. She possesses a potentially dangerous power, and Jack is torn by the feelings he's developing for her and the fear of what she might be capable of. Is she the naive young girl she seems to be, or could she be earth's last great hope?