Everyone and everything in the village of Biggersville is giant sized. After all, it is a village of Giants! Giant trees, giant houses, giant animals, and all the giant villagers. Everyone and everything, except for a seven-year-old boy named Little Otto. He seems to have stopped growing. Even with wonderful, supportive parents like Big Otto and Gertie DeGrande and his very best friend Lizzie, who is a year younger and twice as tall, Little Otto can't help but feel that he is too different to fit in. He can ride Gretchen the Giant Goose and swing on Bessie the Giant Cow's tail and join Lizzie in all their great adventures together, but deep down, all he dreams about is being the same as everyone else. It's no fun feeling "small."

Until one day, when his best friend Lizzie has gone missing after school and the whole village was out searching for her, they turned to Little Otto to save Lizzie, and he learned that what made him feel "different" all this time was exactly what would save the day and his best friend! And that loving and being true to who you are will always make you a feel like a giant to yourself and to others.