Almost six long years have passed since Carmela Santiago witnessed the hitman she loved assassinate her father. Now she is ready to exact her plan of revenge against him and the people he loves. Carmela will stop at nothing to tear his family apart.

Running her father's drug smuggling empire, she will use every resource at her disposal, including money, sex, the men in her life, and her very own cold-blooded sicario, to help her carry out her deeds.

Nicholas D'Angelo, the contract killer, once employed by Carmela's father has his family safely tucked away in a compound in Tuscany, Italy. Many times he has regretted his decision to let Carmela live.

Forced by the government to return to the United States and resume the life of a killer, Nick knows will put his family in jeopardy. Carmela Santiago has the means to destroy him and all those he holds dear.

Carmela moves forward with her plan of revenge, but her closest allies are fast becoming her enemies. As she pushes things to the limit, Carmela gets caught in her own web of lies, murder, and deceit. With the stakes rising higher, she is determined to win. Nick will use everything at his disposal to stop her.