The most celebrated woman writer of the Italian Renaissance, Vittoria Colonna was known for her elegant poetry and use of the sonnet form to explore pressing religious questions. The selection of Colonna's letters presented here for the first time in a collected edition was written to and from writers, artists, popes, cardinals, employees, and family members. Together they place Colonna at the center of intersecting epistolary networks as a political actor, theological thinker, literary practitioner, and caring friend. Revealing a historical woman speaking and acting with force in the world, these letters constitute a vital tool for anyone seeking to understand Colonna's literary works. Newly translated, this work reveals new aspects and faces of the most celebrated woman writer of the Italian Renaissance.