The Brain and the Spirit invites readers to embark on a practice of listening to the Christ story through the earpiece of neuroscience. After many years steeped in brain science, the author had an unexpected encounter with a theologian, James Alison, whose trust in God and forgiveness toward others appeared to defy neurobiological explanation. How did his encounter with the Christ story produce in him the Christlike responses that it did? This question launched the author on a thrilling quest to listen to the scriptures and take up questions of creation, humanity, sin, Jesus, salvation, the Spirit, and the body of Christ, to hear what might get amplified by our ever-expanding understanding of the human brain. Readers are invited to eavesdrop on the twists and turns of the author's story and take up their own practice of listening to the Spirit, scripture and theology through the earpiece of neuroscience, and to become curious how the Christ story may spark trust which unlocks our brain's capacity to engage reality with relationality, kindness, creativity, and access to joy.