This work describes detailed and historical information of how humans ended up milking a gland from a desert amphibian to induce the strongest state of Awareness; On how to collect properly and ethically venom from the Sonoran desert toad, and especially how to facilitate the state induced by its entheogenic secretion in a ceremonial setting. The author shares his experience of the thousands of processes around the world in an attempt to establish Guidelines for Entheogenic exploration with the now called God Molecule.