It's 1947, and in the wake of World War II, the Holocaust, atomic bombs, and a new era in America, four boys in New York City play baseball.

Dino, Sean, Bernie, and Aram have, on the surface, very little in common. Dino is the charismatic and outgoing eldest son of a loving Italian family. Sean is the Irish baseball star, his brother dead in the war and his father embalmed in his own grief. Bernie is brash and flirty, but the German-Jewish family he comes from carries heavy scars. And Aram, the studious and sensitive son of Armenian parents, has his sights set on a future in academia.

Despite their differences, their time playing baseball together binds them into a team-into "The Infielders," as they call themselves. Theirs becomes a deep and meaningful friendship that stretches beyond high school, into adulthood, even as their paths in life diverge. But when disaster and betrayal strike their group, the Infielders must come together to determine how-and if-their fellowship will survive.