Sadly, Timothy Fuller is too old and infirm to continue caring for his beloved Pomeranian, Stewie, who is also elderly. But finding Stewie a new home has been challenging. Fortunately, Liz Denton and her son, Ben, are on the case. With two beagles and a calico currently residing under their roof, they're always ready to provide care in an emergency.

But a rival rescue group is already there when they show up at the Fuller house--along with a nurse and Mr. Fuller's sour-faced son. After an unpleasant argument, they reschedule the pickup for later. But by the time she gets back, Stewie is an orphan. Mr. Fuller has been found with a knife in his back. And Ben, who'd stopped off to visit one of Mr. Fuller's neighbors, has been collared. Now solving the mystery is Liz's only hope for rescuing her own son . . .